One of the more challenging aspects of the trajectory design for the OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer) mission at asteroid Bennu was maneuvering while in orbit. The orbital dynamics were highly perturbed by various sources, most notably solar radiation pressure, which degraded accuracy of long term predictions of the spacecraft’s location in orbit. Generally, the Navigation team had to solve three separate issues: correcting a perturbed orbit, changing to a different orbit, or phasing the orbit to place the spacecraft at a specific location at a specific time. The team composed a common framework using up to two maneuvers that could solve all of these problems using an identical schedule that allowed for consistent planning long before the final trajectory could be designed. This orbit trim strategy was successfully used for the first time in the Orbital B phase of the mission to maximize the duration of usable observing geometry in a time-variable orbit with strict operational limits. It was used an additional 3 times throughout the mission to adjust and/or change the orbit, most notably altering the orbit in the weeks prior to the successful Touch-And-Go (TAG) sample collection attempt. This same strategy was used to phase the orbit a total 10 times in preparation for each of the science sorties over potential sample sites, the TAG Rehearsals, and TAG. The trim strategy was demonstrated to be robust and performed exceptionally well in all aspects, which proved critical to a successful sample collection.