TY - JOUR
T1 - Oscillatory reactivity to effortful cognitive processing in the subthalamic nucleus and internal pallidum
T2 - a depth electrode EEG study
AU - Bočková, Martina
AU - Chládek, Jan
AU - Jurák, Pavel
AU - Halámek, Josef
AU - Rapcsak, Steven Z.
AU - Baláž, Marek
AU - Chrastina, Jan
AU - Rektor, Ivan
N1 - Funding Information:
This research has been financially supported by the Ministry of Education, Youth and Sports of the Czech Republic under the project CEITEC 2020 (LQ1601). The study was also supported by Grant AZV 16-33798A and has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 734718 (CoBeN). The technical part of this study was supported by Grant GA GACR P103/11/0933. The technical part of the study was also supported with institutional support RVO:68081731, MEYS CR (LO1212) together with EC (ALISI No. CZ.1.05/2.1.00/01.0017). We wish to thank prof. Novák and Ing. Říha for their cooperation.
Publisher Copyright:
© 2017, Springer-Verlag Wien.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - This study investigates how complex motor-cognitive activities are processed in the subthalamic nucleus (STN) and internal globus pallidum (GPi), as adverse neuropsychiatric effects may accompany deep brain stimulation (DBS), mainly in Parkinson’s disease (PD) and STN-DBS. Dystonia patients with GPi-DBS electrodes (n = 5) and PD subjects (n = 5) with STN-DBS electrodes performed two tasks: (1) copying letters; and (2) writing any letter other than that appearing on the monitor. The cognitive load of the second task was greater than that of the first. Intracranial local field potentials (LFPs) were analysed. A beta power decrease was the main correlate of the enhanced cognitive load during the second task in both structures, with a lateralization to the left side, mainly in the GPi. A gamma power increase linked with the increased cognitive activity was observed only in the STN. Differences were also observed in the theta and alpha bandpasses. Beta ERD reactivity seems to be essential during the processing of complex motor-cognitive tasks, increases with enhanced cognitive effort, and was observed in both the STN and GPi. Oscillatory reactivity to effortful cognitive processing in other frequency bands was less consistent, with differences between the studied nuclei. Lateralization of activity related to cognitive factors was observed mainly in the GPi.
AB - This study investigates how complex motor-cognitive activities are processed in the subthalamic nucleus (STN) and internal globus pallidum (GPi), as adverse neuropsychiatric effects may accompany deep brain stimulation (DBS), mainly in Parkinson’s disease (PD) and STN-DBS. Dystonia patients with GPi-DBS electrodes (n = 5) and PD subjects (n = 5) with STN-DBS electrodes performed two tasks: (1) copying letters; and (2) writing any letter other than that appearing on the monitor. The cognitive load of the second task was greater than that of the first. Intracranial local field potentials (LFPs) were analysed. A beta power decrease was the main correlate of the enhanced cognitive load during the second task in both structures, with a lateralization to the left side, mainly in the GPi. A gamma power increase linked with the increased cognitive activity was observed only in the STN. Differences were also observed in the theta and alpha bandpasses. Beta ERD reactivity seems to be essential during the processing of complex motor-cognitive tasks, increases with enhanced cognitive effort, and was observed in both the STN and GPi. Oscillatory reactivity to effortful cognitive processing in other frequency bands was less consistent, with differences between the studied nuclei. Lateralization of activity related to cognitive factors was observed mainly in the GPi.
KW - Complex cognitive functions
KW - Deep brain stimulation
KW - ERD/S
KW - Internal globus pallidum
KW - Lateralization
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=85017182950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017182950&partnerID=8YFLogxK
U2 - 10.1007/s00702-017-1719-6
DO - 10.1007/s00702-017-1719-6
M3 - Article
C2 - 28389718
AN - SCOPUS:85017182950
SN - 0300-9564
VL - 124
SP - 841
EP - 852
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 7
ER -