Orthologous gene-expression profiling in multi-species models: search for candidate genes

Dmitry N. Grigoryev; Shwu Fan Ma; Rafael A. Irizarry; Shui Qing Ye; John Quackenbush; Joe Gn Garcia

doi:10.1186/gb-2004-5-5-r34

Orthologous gene-expression profiling in multi-species models: search for candidate genes

Dmitry N. Grigoryev
, Shwu Fan Ma
, Rafael A. Irizarry
, Shui Qing Ye
, John Quackenbush
, Joe Gn Garcia

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

Original language	English (US)
Article number	R34
Journal	Genome biology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1186/gb-2004-5-5-r34
State	Published - May 2004
Externally published	Yes

Keywords

Acute Lung Injury
Additional Data File
Gene Ontology
Mechanical Stretch
U133A Array

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/gb-2004-5-5-r34

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title = "Orthologous gene-expression profiling in multi-species models: search for candidate genes",

abstract = "Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.",

keywords = "Acute Lung Injury, Additional Data File, Gene Ontology, Mechanical Stretch, U133A Array",

author = "Grigoryev, \{Dmitry N.\} and Ma, \{Shwu Fan\} and Irizarry, \{Rafael A.\} and Ye, \{Shui Qing\} and John Quackenbush and Garcia, \{Joe Gn\}",

note = "Publisher Copyright: {\textcopyright} 2004, Grigoryev et al.; licensee BioMed Central Ltd.",

year = "2004",

month = may,

doi = "10.1186/gb-2004-5-5-r34",

language = "English (US)",

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T2 - search for candidate genes

AU - Grigoryev, Dmitry N.

AU - Ma, Shwu Fan

AU - Irizarry, Rafael A.

AU - Ye, Shui Qing

AU - Quackenbush, John

AU - Garcia, Joe Gn

PY - 2004/5

Y1 - 2004/5

N2 - Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

AB - Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

KW - Acute Lung Injury

KW - Additional Data File

KW - Gene Ontology

KW - Mechanical Stretch

KW - U133A Array

UR - https://www.scopus.com/pages/publications/4644262045

UR - https://www.scopus.com/pages/publications/4644262045#tab=citedBy

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SN - 1474-7596

VL - 5

JO - Genome biology

JF - Genome biology

IS - 5

M1 - R34

ER -

Orthologous gene-expression profiling in multi-species models: search for candidate genes

Abstract

Keywords

ASJC Scopus subject areas

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