Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine

N. K. Berdinskikh; N. A. Ignatenko; S. P. Zaletok; K. P. Ganina; V. A. Chorniy

doi:10.1002/ijc.2910470404

Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine

N. K. Berdinskikh, N. A. Ignatenko, S. P. Zaletok, K. P. Ganina, V. A. Chorniy

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.

Original language	English (US)
Pages (from-to)	496-498
Number of pages	3
Journal	International Journal of Cancer
Volume	47
Issue number	4
DOIs	https://doi.org/10.1002/ijc.2910470404
State	Published - Feb 20 1991

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.",

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AU - Ignatenko, N. A.

AU - Zaletok, S. P.

AU - Ganina, K. P.

AU - Chorniy, V. A.

PY - 1991/2/20

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AB - Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.

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Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine

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