Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D2O

Xiang Meng; Yue Dong; Qiangqiang Liu; Wei Wang

doi:10.1039/d3cc04634f

Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D₂O

Xiang Meng, Yue Dong, Qiangqiang Liu, Wei Wang

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We report a straightforward H/D exchange method for the synthesis of α-deuterated primary amines from a diverse set of primary amines with high levels of deuteration and chemo- and site selectivity and preparative utility. This cost-effective strategy enables the direct conversion of primary amines to α-deuterated counterparts using D₂O as the deuterium source under mild reaction conditions without requiring additional functionality manipulation and with minimal byproduct production.

Original language	English (US)
Pages (from-to)	296-299
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	3
DOIs	https://doi.org/10.1039/d3cc04634f
State	Published - Nov 28 2023

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d3cc04634f

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abstract = "We report a straightforward H/D exchange method for the synthesis of α-deuterated primary amines from a diverse set of primary amines with high levels of deuteration and chemo- and site selectivity and preparative utility. This cost-effective strategy enables the direct conversion of primary amines to α-deuterated counterparts using D2O as the deuterium source under mild reaction conditions without requiring additional functionality manipulation and with minimal byproduct production.",

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AU - Meng, Xiang

AU - Dong, Yue

AU - Liu, Qiangqiang

AU - Wang, Wei

PY - 2023/11/28

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Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D₂O

Abstract

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