Organoid Models of Human Gastrointestinal Development and Disease

Priya H. Dedhia, Nina Bertaux-Skeirik, Yana Zavros, Jason R. Spence

Research output: Contribution to journalReview articlepeer-review

156 Scopus citations

Abstract

We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for decades in GI research. Organoids are derived from primary tissues and have the capacity for long-term growth. They contain varying levels of cellular complexity and physiological similarity to native organ systems. We review the latest discoveries from studies of tissue-derived and pluripotent stem cell-derived intestinal, gastric, esophageal, liver, and pancreatic organoids. These studies have provided important insights into GI development, tissue homeostasis, and disease and might be used to develop personalized medicines.

Original languageEnglish (US)
Pages (from-to)1098-1112
Number of pages15
JournalGastroenterology
Volume150
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Gastrointestinal Development
  • Gastrointestinal Disease
  • Gastrointestinal Regeneration
  • Gut Organoids

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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