Organocatalytic enantioselective Strecker reaction of cyclic trifluoromethyl-ketoimines

Hexin Xie, Aiguo Song, Xixi Song, Xinshuai Zhang, Wei Wang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A quinine thiourea promoted enantioselective Strecker reaction of cyclic ketoimines with TMSCN has been developed. The process affords new enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

Original languageEnglish (US)
Pages (from-to)1409-1411
Number of pages3
JournalTetrahedron Letters
Issue number11
StatePublished - Mar 13 2013
Externally publishedYes


  • Amine thiourea
  • Ketoimines
  • Organocatalysis
  • Strecker reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Organocatalytic enantioselective Strecker reaction of cyclic trifluoromethyl-ketoimines'. Together they form a unique fingerprint.

Cite this