Organocatalytic enantioselective Strecker reaction of cyclic trifluoromethyl-ketoimines

Hexin Xie, Aiguo Song, Xixi Song, Xinshuai Zhang, Wei Wang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A quinine thiourea promoted enantioselective Strecker reaction of cyclic ketoimines with TMSCN has been developed. The process affords new enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

Original languageEnglish (US)
Pages (from-to)1409-1411
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number11
DOIs
StatePublished - Mar 13 2013
Externally publishedYes

Keywords

  • Amine thiourea
  • Ketoimines
  • Organocatalysis
  • Strecker reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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