Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes

Hao Li, Yafei Ji, Jian Li, Shilei Zhang, Chenguang Yu, Wei Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A new organocatalytic enantioselective Michael addition of α-fluoromalonate to enals has been developed. The process is efficiently catalyzed by readily available chiral diphenylpyrolinol TES ether under mild reaction conditions to afford versatile highly enantioenriched fluorinated aldehydes.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalScience China Chemistry
Volume53
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Chiral fluorinated compounds
  • Michael addition
  • Organocatalysis
  • α,β-unsaturated aldehydes

ASJC Scopus subject areas

  • Chemistry(all)

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