Organocatalytic enantioselective Michael addition of thioacetic acid to enones

Hao Li, Liansuo Zu, Jian Wang, Wei Wang

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


An enantioselective, organocatalytic Michael addition reaction of thioacetic acid with enones has been developed. The process, catalyzed by a chiral bifunctional amine thiourea, furnishes products in excellent yields with up to 63% ee.

Original languageEnglish (US)
Pages (from-to)3145-3148
Number of pages4
JournalTetrahedron Letters
Issue number18
StatePublished - May 1 2006
Externally publishedYes


  • Amine thiourea
  • Asymmetric organocatalysis
  • Enones
  • Michael addition reaction
  • Thioacetic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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