Abstract
An efficient aminocatalytic enantioselective Michael addition of readily available cyclic hemiacetals to nitroolefins has been developed. The strategy serves as a powerful approach to synthetically valuable chiral 3-substituted tetrahydrofurans (THFs) and tetrahydropyrans (THPs). The synthetic utilities of the versatile Michael adducts also have been demonstrated in the synthesis of 2,3-disubstituted cyclic ethers, α-substituted lactones and venlafaxine analogues.
Original language | English (US) |
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Pages (from-to) | 4769-4775 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 13 |
Issue number | 16 |
DOIs | |
State | Published - Apr 28 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry