Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: Formation of two contiguous quaternary centered 3-substituted 3- hydroxyindol-2-ones

Fei Xue; Shilei Zhang; Lu Liu; Wenhu Duan; Wei Wang

doi:10.1002/asia.200900243

Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: Formation of two contiguous quaternary centered 3-substituted 3- hydroxyindol-2-ones

Fei Xue, Shilei Zhang, Lu Liu, Wenhu Duan, Wei Wang

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency.

Original language	English (US)
Pages (from-to)	1664-1667
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	4
Issue number	11
DOIs	https://doi.org/10.1002/asia.200900243
State	Published - Nov 2 2009
Externally published	Yes

Keywords

Aldehydes
Aldol
Isatins
Organocatalysis

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1002/asia.200900243

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Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins : Formation of two contiguous quaternary centered 3-substituted 3- hydroxyindol-2-ones. / Xue, Fei; Zhang, Shilei; Liu, Lu; Duan, Wenhu; Wang, Wei.

In: Chemistry - An Asian Journal, Vol. 4, No. 11, 02.11.2009, p. 1664-1667.

Research output: Contribution to journal › Article › peer-review

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abstract = "Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency.",

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AU - Zhang, Shilei

AU - Liu, Lu

AU - Duan, Wenhu

AU - Wang, Wei

PY - 2009/11/2

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AB - Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency.

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KW - Aldol

KW - Isatins

KW - Organocatalysis

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Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: Formation of two contiguous quaternary centered 3-substituted 3- hydroxyindol-2-ones

Abstract

Keywords

ASJC Scopus subject areas

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