Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: Formation of two contiguous quaternary centered 3-substituted 3- hydroxyindol-2-ones

Fei Xue, Shilei Zhang, Lu Liu, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency.

Original languageEnglish (US)
Pages (from-to)1664-1667
Number of pages4
JournalChemistry - An Asian Journal
Volume4
Issue number11
DOIs
StatePublished - Nov 2 2009
Externally publishedYes

Keywords

  • Aldehydes
  • Aldol
  • Isatins
  • Organocatalysis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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