Organocatalytic enantioselective conjugate additions to enones

Jian Wang; Hao Li; Liansuo Zu; Wei Jiang; Hexin Xie; Wenhu Duan; Wei Wang

doi:10.1021/ja065187u

Organocatalytic enantioselective conjugate additions to enones

Jian Wang, Hao Li, Liansuo Zu, Wei Jiang, Hexin Xie, Wenhu Duan, Wei Wang

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.

Original language	English (US)
Pages (from-to)	12652-12653
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	39
DOIs	https://doi.org/10.1021/ja065187u
State	Published - Oct 4 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja065187u

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abstract = "Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.",

author = "Jian Wang and Hao Li and Liansuo Zu and Wei Jiang and Hexin Xie and Wenhu Duan and Wei Wang",

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T1 - Organocatalytic enantioselective conjugate additions to enones

AU - Wang, Jian

AU - Li, Hao

AU - Zu, Liansuo

AU - Jiang, Wei

AU - Xie, Hexin

AU - Duan, Wenhu

AU - Wang, Wei

PY - 2006/10/4

Y1 - 2006/10/4

N2 - Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.

AB - Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.

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Organocatalytic enantioselective conjugate additions to enones

Abstract

ASJC Scopus subject areas

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