Abstract
(Chemical Equation Presented) A cascade of possibility: A novel and highly enantioselective cascade Michael-aldol condensation reaction of α,β-unsaturated aldehydes with dimethyl malonate aldehyde has been developed. The process, efficiently catalyzed by a simple chiral diphenylprolinol TES ether, serves as a powerful approach to the preparation of highly functionalized chiral cyclopentenes with the formation of two new C-C bonds. TES = triethylsilyl.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9050-9053 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 46 |
| Issue number | 47 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
Keywords
- Aldehydes
- Cascade reactions
- Cyclopentenes
- Michael-aldol reaction
- Organocatalysis
ASJC Scopus subject areas
- Catalysis
- General Chemistry
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