Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

Hao Li; Shilei Zhang; Chenguang Yu; Xixi Song; Wei Wang

doi:10.1039/b900777f

Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

Hao Li, Shilei Zhang, Chenguang Yu, Xixi Song, Wei Wang

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Organocatalytic enantioselective conjugate addition of α- fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.

Original language	English (US)
Pages (from-to)	2136-2138
Number of pages	3
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/b900777f
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b900777f

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title = "Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters",

abstract = "Organocatalytic enantioselective conjugate addition of α- fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.",

author = "Hao Li and Shilei Zhang and Chenguang Yu and Xixi Song and Wei Wang",

year = "2009",

doi = "10.1039/b900777f",

language = "English (US)",

pages = "2136--2138",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "16",

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TY - JOUR

T1 - Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

AU - Li, Hao

AU - Zhang, Shilei

AU - Yu, Chenguang

AU - Song, Xixi

AU - Wang, Wei

PY - 2009

Y1 - 2009

N2 - Organocatalytic enantioselective conjugate addition of α- fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.

AB - Organocatalytic enantioselective conjugate addition of α- fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.

UR - https://www.scopus.com/pages/publications/64549143856

UR - https://www.scopus.com/inward/citedby.url?scp=64549143856&partnerID=8YFLogxK

U2 - 10.1039/b900777f

DO - 10.1039/b900777f

M3 - Article

C2 - 19360171

AN - SCOPUS:64549143856

SN - 1359-7345

SP - 2136

EP - 2138

JO - Chemical Communications

JF - Chemical Communications

IS - 16

ER -

Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

Abstract

ASJC Scopus subject areas

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