Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

Hao Li, Shilei Zhang, Chenguang Yu, Xixi Song, Wei Wang

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Organocatalytic enantioselective conjugate addition of α- fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.

Original languageEnglish (US)
Pages (from-to)2136-2138
Number of pages3
JournalChemical Communications
Issue number16
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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