Organocatalytic asymmetric conjugate addition of thioacetic acid to β-nitrostyrenes

Hao Li, Jian Wang, Liansuo Zu, Wei Wang

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

A method for organocatalytic, enantioselective Michael addition reactions of thioacetic acid with a range of trans-β-nitrostyrenes has been developed. The processes, promoted by the chiral amine thiourea organocatalyst, take place in high yields with up to 70% ee.

Original languageEnglish (US)
Pages (from-to)2585-2589
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number15
DOIs
StatePublished - Apr 10 2006
Externally publishedYes

Keywords

  • Amine thiourea
  • Asymmetric organocatalysis
  • Michael addition reaction
  • Nitroolefins
  • Thioacetic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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