Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: Highly enantioselective synthesis of chiral: N, O -ketals

Ding Zhou, Xueting Yu, Jian Zhang, Wei Wang, Hexin Xie

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

Original languageEnglish (US)
Pages (from-to)6193-6196
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number26
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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