Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: Highly enantioselective synthesis of chiral: N, O -ketals

Ding Zhou; Xueting Yu; Jian Zhang; Wei Wang; Hexin Xie

doi:10.1039/c6ob00890a

Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: Highly enantioselective synthesis of chiral: N, O -ketals

Ding Zhou, Xueting Yu, Jian Zhang, Wei Wang, Hexin Xie

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

Original language	English (US)
Pages (from-to)	6193-6196
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	26
DOIs	https://doi.org/10.1039/c6ob00890a
State	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c6ob00890a

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title = "Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: Highly enantioselective synthesis of chiral: N, O -ketals",

abstract = "A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.",

author = "Ding Zhou and Xueting Yu and Jian Zhang and Wei Wang and Hexin Xie",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6ob00890a",

language = "English (US)",

volume = "14",

pages = "6193--6196",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "26",

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TY - JOUR

T1 - Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines

T2 - Highly enantioselective synthesis of chiral: N, O -ketals

AU - Zhou, Ding

AU - Yu, Xueting

AU - Zhang, Jian

AU - Wang, Wei

AU - Xie, Hexin

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

AB - A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.

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U2 - 10.1039/c6ob00890a

DO - 10.1039/c6ob00890a

M3 - Article

C2 - 27271888

AN - SCOPUS:84976885401

SN - 1477-0520

VL - 14

SP - 6193

EP - 6196

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 26

ER -

Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: Highly enantioselective synthesis of chiral: N, O -ketals

Abstract

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