Organic-inorganic nanovesicles for doxorubicin storage and release

Siu Ling Leung, Zhengbao Zha, Weibing Teng, Celine Cohn, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

Original languageEnglish (US)
Pages (from-to)5756-5764
Number of pages9
JournalSoft Matter
Issue number21
StatePublished - Jun 7 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics


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