Organic-inorganic nanovesicles for doxorubicin storage and release

Siu Ling Leung; Zhengbao Zha; Weibing Teng; Celine Cohn; Zhifei Dai; Xiaoyi Wu

doi:10.1039/c2sm07452d

Organic-inorganic nanovesicles for doxorubicin storage and release

Siu Ling Leung, Zhengbao Zha, Weibing Teng, Celine Cohn, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

Original language	English (US)
Pages (from-to)	5756-5764
Number of pages	9
Journal	Soft Matter
Volume	8
Issue number	21
DOIs	https://doi.org/10.1039/c2sm07452d
State	Published - Jun 7 2012

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics

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title = "Organic-inorganic nanovesicles for doxorubicin storage and release",

abstract = "The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.",

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T1 - Organic-inorganic nanovesicles for doxorubicin storage and release

AU - Leung, Siu Ling

AU - Zha, Zhengbao

AU - Teng, Weibing

AU - Cohn, Celine

AU - Dai, Zhifei

AU - Wu, Xiaoyi

PY - 2012/6/7

Y1 - 2012/6/7

N2 - The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

AB - The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

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Organic-inorganic nanovesicles for doxorubicin storage and release

Abstract

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