Order of Magnitude Signal Gain in Magnetic Sector Mass Spectrometry Via Aperture Coding

Evan X. Chen, Zachary E. Russell, Jason J. Amsden, Scott D. Wolter, Ryan M. Danell, Charles B. Parker, Brian R. Stoner, Michael E. Gehm, Jeffrey T. Glass, David J. Brady

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Miniaturizing instruments for spectroscopic applications requires the designer to confront a tradeoff between instrument resolution and instrument throughput [and associated signal-to-background-ratio (SBR)]. This work demonstrates a solution to this tradeoff in sector mass spectrometry by the first application of one-dimensional (1D) spatially coded apertures, similar to those previously demonstrated in optics. This was accomplished by replacing the input slit of a simple 90° magnetic sector mass spectrometer with a specifically designed coded aperture, deriving the corresponding forward mathematical model and spectral reconstruction algorithm, and then utilizing the resulting system to measure and reconstruct the mass spectra of argon, acetone, and ethanol. We expect the application of coded apertures to sector instrument designs will lead to miniature mass spectrometers that maintain the high performance of larger instruments, enabling field detection of trace chemicals and point-of-use mass spectrometry. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)1633-1640
Number of pages8
JournalJournal of the American Society for Mass Spectrometry
Issue number9
StatePublished - Sep 8 2015
Externally publishedYes


  • Coded aperture sector mass spectrometry
  • Computational mass spectrometry
  • Magnetic sector mass spectrometry
  • Miniature mass spectrometry

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy


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