Orbital preservation in patients with esthesioneuroblastoma

Marc W. Herr, Stacey T. Gray, Audrey B. Erman, William T. Curry, Daniel G. Deschler, Derrick T. Lin

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives Surgical resection in addition to adjuvant radiation with or without chemotherapy is the mainstay of treatment for esthesioneuroblastoma (ENB). However, management of patients with orbital involvement remains controversial. Historically, orbital exenteration has been advocated when there is evidence of periorbital invasion. Recently, the indications for orbital exenteration have become more selective and orbital preservation has been advocated. We report our experience with anterior craniofacial resection and orbital preservation in patients with ENB. Design Retrospective review of all patients diagnosed with esthesioneuroblastoma who underwent traditional open anterior craniofacial resection at the Massachusetts General Hospital/Massachusetts Eye and Ear Infirmary Cranial Base Center from 1997 to 2008. Results Sixteen patients were identified with a mean follow-up of 76 months. All patients underwent anterior craniofacial resection via an open approach and adjuvant proton beam radiation. Six of the 16 patients had evidence of either periorbital or lacrimal sac involvement at the time of surgery. All of these patients underwent periorbital resection to negative histologic margins with preservation of the orbit. Conclusion In our study, patients with ENB and periorbital invasion-who were treated with anterior craniofacial resection and periorbital resection with orbital preservation-had no evidence of decreased survival. In all patients, negative histologic margins of the periorbital resection were achieved.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalJournal of Neurological Surgery, Part B: Skull Base
Issue number3
StatePublished - 2013


  • anterior craniofacial resection
  • esthesioneuroblastoma
  • orbital preservation
  • skull base

ASJC Scopus subject areas

  • Clinical Neurology


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