Orbital and optic pathway sarcoidosis: MR findings

R. F. Carmody, M. F. Mafee, J. A. Goodwin, K. Small, C. Haery

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


PURPOSE: To identify and characterize the MR findings of sarcoidosis when it involves the orbit and visual pathways. METHODS: The MR scans of 15 patients, 3 with presumed and 12 with proved orbital or optic pathway sarcoidosis were retrospectively reviewed. RESULTS: Eight patients had MR evidence of optic nerve involvement by sarcoid granuloma. Perineural enhancement was seen in four cases, optic atrophy in one. Three who had had unenhanced scans showed optic nerve enlargement. Nine patients had optic chiasmal involvement. One patient had increased T2 signal in the optic radiations. Three patients had orbital masses that had MR signal characteristics similar to pseudotumor. Five patients had periventricular white matter abnormalities closely resembling multiple sclerosis. CONCLUSIONS: Sarcoidosis should be considered in the differential diagnosis of optic nerve or nerve sheath enhancement on MR. Orbital sarcoidosis has MR characteristics very similar to pseudotumor.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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