Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma

Ronald Ross Watson, Sherma Zibadi, Houshang Rafatpanah, Farahzad Jabbari, Ramin Ghasemi, Javad Ghafari, Hadi Afrasiabi, Lai Yeap Foo, Reza Faridhosseini

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical symptoms of asthma of the PFP extract-treated group were moderated significantly compared to the baseline. The prevalence of wheeze, cough, as well as shortness of breath was reduced significantly in group treated with PFP extract (P < .05), whereas the placebo caused no significant improvement. Purple passion fruit peel extract supplementation resulted in a marked increase in forced vital capacity (P < .05) as placebo showed no effect. However, no significant improvement was observed in the forced expiratory volume at 1 second of those supplemented with PFP extract. No adverse effect was reported by any of study participants. The PFP extract may be safely offered to asthmatic subjects as an alternative treatment option to reduce clinical symptoms.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalNutrition Research
Issue number3
StatePublished - Mar 2008


  • Asthma
  • Bioflavonoids
  • FEV
  • FVC
  • Human
  • NO
  • Nitric oxide
  • PFP
  • Purple passion fruit
  • forced expiratory volume at 1 second
  • forced vital capacity
  • iNOS
  • inducible nitric oxide synthase
  • nitric oxide
  • purple passion fruit peel

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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