TY - JOUR
T1 - Optogenetic Activation of an Inhibitory Network Enhances Feedforward Functional Connectivity in Auditory Cortex
AU - Hamilton, Liberty S.
AU - Sohl-Dickstein, Jascha
AU - Huth, Alexander G.
AU - Carels, Vanessa M.
AU - Deisseroth, Karl
AU - Bao, Shaowen
N1 - Funding Information:
The authors thank Fritz Sommer, Michael DeWeese, Daniel Feldman, David Larue, Asako Miyakawa, Robert Gibboni, Aaron Koralek, and Colleen Kirkhart for helpful comments and advice. The authors also thank Seung-Hee Lee for advice on virus injection procedures and histology and Trevor Flynn for assistance in cell counting analyses. This work was supported by the National Institute on Deafness and Other Communication Disorders (DC009259), a William Orr Dingwall Neurolinguistics Dissertation Fellowship (to A.G.H), and a National Science Foundation Graduate Research Fellowship (to L.S.H.).
PY - 2013/11/20
Y1 - 2013/11/20
N2 - The mammalian neocortex is a highly interconnected network of different types of neurons organized intoboth layers and columns. Overlaid on this structural organization is a pattern of functional connectivity that can be rapidly and flexibly altered during behavior. Parvalbumin-positive (PV+) inhibitory neurons, which are implicated in cortical oscillations and can change neuronal selectivity, may play a pivotal role in these dynamic changes. We found that optogenetic activation of PV+ neurons in the auditory cortex enhanced feedforward functional connectivity in the putative thalamorecipient circuit and in cortical columnar circuits. In contrast, stimulation of PV+ neurons induced no change in connectivity between sites in the same layers. The activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral or feedback, information flow in cortical circuits. Functionally, it may preferentially enhance the contribution of bottom-up sensory inputs to perception
AB - The mammalian neocortex is a highly interconnected network of different types of neurons organized intoboth layers and columns. Overlaid on this structural organization is a pattern of functional connectivity that can be rapidly and flexibly altered during behavior. Parvalbumin-positive (PV+) inhibitory neurons, which are implicated in cortical oscillations and can change neuronal selectivity, may play a pivotal role in these dynamic changes. We found that optogenetic activation of PV+ neurons in the auditory cortex enhanced feedforward functional connectivity in the putative thalamorecipient circuit and in cortical columnar circuits. In contrast, stimulation of PV+ neurons induced no change in connectivity between sites in the same layers. The activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral or feedback, information flow in cortical circuits. Functionally, it may preferentially enhance the contribution of bottom-up sensory inputs to perception
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U2 - 10.1016/j.neuron.2013.08.017
DO - 10.1016/j.neuron.2013.08.017
M3 - Article
C2 - 24267655
AN - SCOPUS:84888039147
SN - 0896-6273
VL - 80
SP - 1066
EP - 1076
JO - Neuron
JF - Neuron
IS - 4
ER -