Optimizing imaging hardware for estimation tasks

Matthew A. Kupinski, Eric Clarkson, Kevin Gross, John W. Hoppin

Research output: Contribution to journalConference articlepeer-review

8 Scopus citations


Medical imaging is often performed for the purpose of estimating a clinically relevant parameter. For example, cardiologists are interested in the cardiac ejection fraction, the fraction of blood pumped out of the left ventricle at the end of each heart cycle. Even when the primary task of the imaging system is tumor detection, physicians frequently want to estimate parameters of the tumor, e.g. size and location. For signal-detection tasks, we advocate that the performance of an ideal observer be employed as the figure of merit for optimizing medical imaging hardware. We have examined the use of the minimum variance of the ideal, unbiased estimator as a figure of merit for hardware optimization. The minimum variance of the ideal, unbiased estimator can be calculated using the Fisher information matrix. To account for both image noise and object variability, we used a statistical method known as Markov-chain Monte Carlo. We employed a lumpy object model and simulated imaging systems to compute our figures of merit. We have demonstrated the use of this method in comparing imaging systems for estimation tasks.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2003
EventMedical Imaging 2003: Image Perception, Observer Performance, and Technology Assessment - San Diego, CA, United States
Duration: Feb 18 2003Feb 20 2003


  • Estimation tasks
  • Fisher information
  • Image quality

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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