Optimization of thoracic spiral CT: Effects of iodinated contrast medium concentration

Geoffrey D. Rubin, Michael J. Lane, Daniel A. Bloch, Ann N. Leung, Paul Stark

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


PURPOSE: To determine the effect of varying iodine concentration on arterial enhancement and perivenous artifact during thoracic spiral computed tomographic (CT) scanning. MATERIALS AND METHODS: One hundred thirty-eight outpatients received 15.0 g (n = 76) or 22.5 g (n = 62) of iodine (300 mg/mL iodine) while undergoing thoracic spiral CT. Patients received either undiluted contrast medium, 1:1 normal saline dilution, or 3:1 normal saline dilution. Contrast medium was injected at a flow rate determined to deliver the entire iodine dose within 40 seconds. Attenuation was measured within arteries and veins. Three blinded thoracic radiologists independently graded perivenous artifact and arterial enhancement. RESULTS: Perivenous artifacts were statistically significantly reduced with successive iodine dilution (P < .002). Arterial enhancement was statistically significantly better with 15.0 g of iodine diluted 1:1 when compared with the same iodine dose undiluted or diluted 3:1 (P < .01). Arterial enhancement achieved with 15.0 g of iodine diluted 1:1 was not statistically significantly lower than that achieved with 22.5 g of iodine diluted 1:1 (P > .31); however, venous artifact was greater with 22.5 g of iodine (P < .004). CONCLUSION: Reduced iodine concentration appears to diminish perivenous artifact and to result in improved arterial enhancement during thoracic spiral CT.

Original languageEnglish (US)
Pages (from-to)785-791
Number of pages7
Issue number3
StatePublished - Dec 1996
Externally publishedYes


  • Arteries, CT
  • Computed tomography (CT), artifact
  • Computed tomography (CT), contrast enhancement
  • Veins, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Optimization of thoracic spiral CT: Effects of iodinated contrast medium concentration'. Together they form a unique fingerprint.

Cite this