Optimization of a coded aperture coherent scatter spectral imaging system for medical imaging

Joel A. Greenberg, Manu N. Lakshmanan, David J. Brady, Anuj J. Kapadia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations


Coherent scatter X-ray imaging is a technique that provides spatially-resolved information about the molecular structure of the material under investigation, yielding material-specific contrast that can aid medical diagnosis and inform treatment. In this study, we demonstrate a coherent-scatter imaging approach based on the use of coded apertures (known as coded aperture coherent scatter spectral imaging1, 2) that enables fast, dose-efficient, high-resolution scatter imaging of biologically-relevant materials. Specifically, we discuss how to optimize a coded aperture coherent scatter imaging system for a particular set of objects and materials, describe and characterize our experimental system, and use the system to demonstrate automated material detection in biological tissue.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationPhysics of Medical Imaging
EditorsChristoph Hoeschen, Despina Kontos, Christoph Hoeschen
ISBN (Electronic)9781628415025
StatePublished - 2015
Externally publishedYes
EventMedical Imaging 2015: Physics of Medical Imaging - Orlando, United States
Duration: Feb 22 2015Feb 25 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2015: Physics of Medical Imaging
Country/TerritoryUnited States


  • Coded aperture
  • Material identification
  • X-ray contrast
  • X-ray diffraction imaging
  • X-ray tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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