TY - JOUR
T1 - Optimal visual perception and detection of oral cavity neoplasia
AU - Utzinger, Urs
AU - Bueeler, Michael
AU - Oh, Sanghoon
AU - Heintzelman, Douglas L.
AU - Svistun, Ekaterina S.
AU - Abd-El-Barr, Muhammad
AU - Gillenwater, Ann
AU - Richards-Kortum, Rebecca
N1 - Funding Information:
Manuscript received February 20, 2002; revised November 22, 2002. This work was supported by the Texas Higher Education Coordinating Board. Asterisk indicates corresponding author. U. Utzinger is with the Department of Biomedical Engineering and Obstetrics and Gynecology, the University of Arizona, Tucson, AZ 85724 USA. M. Bueeler is with the Institute of Biomedical Engineering and Medical Informatics, Swiss Federal Institute of Technology, University of Zürich, CH-8092 Zürich, Switzerland. S. Oh, E. S. Svistun, and M. Abd-El-Barr are with the Biomedical Engineering Department, The University of Texas at Austin, Austin, TX 78712 USA. D. L. Heintzelman was with the Department of Biomedical Engineering Program, The University of Texas at Austin, Austin, TX 78712 USA. He is now with the School of Medicine, Indiana University, Indianapolis IN 46202 USA. A. Gillenwater is with the Department of Head and Neck Surgery, M.D. Anderson Cancer Center, the University of Texas, Houston, TX 77030 USA. R. Richards-Kortum is with the Biomedical Engineering Department, The University of Texas at Austin, Austin, TX 78712 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2003.808832
PY - 2003/3/1
Y1 - 2003/3/1
N2 - The most common way to detect disease is by visual inspection of the suspect tissue. However, the human eye is not optimized for this task because the perceived spectrum of light is divided into three channels, all of which have overlapping spectral sensitivity curves. Here, we present new methods to optimize visually perceived contrast based on spectral differences between normal and abnormal tissue. We apply these methods to the perception of fluorescence emission from the oral cavity. Abnormalities in the oral cavity are optimally perceived when the excitation is between 420-440 nm. To optimally visualize fluorescence at 340-nm excitation, the emission should be observed through a blue bandpass filter transmitting light at 430 nm.
AB - The most common way to detect disease is by visual inspection of the suspect tissue. However, the human eye is not optimized for this task because the perceived spectrum of light is divided into three channels, all of which have overlapping spectral sensitivity curves. Here, we present new methods to optimize visually perceived contrast based on spectral differences between normal and abnormal tissue. We apply these methods to the perception of fluorescence emission from the oral cavity. Abnormalities in the oral cavity are optimally perceived when the excitation is between 420-440 nm. To optimally visualize fluorescence at 340-nm excitation, the emission should be observed through a blue bandpass filter transmitting light at 430 nm.
KW - Autofluorescence
KW - Color difference
KW - Diagnosis
KW - Ideal observer
KW - Oral cavity
KW - Visual system
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U2 - 10.1109/TBME.2003.808832
DO - 10.1109/TBME.2003.808832
M3 - Article
C2 - 12669997
AN - SCOPUS:0344406101
SN - 0018-9294
VL - 50
SP - 396
EP - 399
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 3
ER -