Optimal fluorescence imaging of atherosclerotic human tissue

C. M. Connor Davenport, A. L. Alexander, A. F. Gmitro

Research output: Contribution to journalConference articlepeer-review


Multispectral imaging was investigated as a technique to exploit the spatial and spectral information available in the diagnosis of atherosclerosis. A diagnostic system is proposed that could provide direct viewing of a standard endoscopic or a total-fluorescence image. In addition, multiple spectral-feature images, each associated with a separate, narrow spectral band, could be obtained and processed to produce an optimized contrast image. In this study, a 'white-light' image and a total-fluorescence image were obtained. In addition, a three-dimensional, multispectral data set was generated, and two methods of utilizing this data were explored: 1) a per-pixel ratio of fluorescence intensities, and 2) an optimized superposition of the spectral-feature images. Fluorescence imaging is found to provide a rich data set possessing great potential for improving the detection and characterization of atheromatous disease.

Original languageEnglish (US)
Pages (from-to)16-27
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1991
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions - Los Angeles, CA, USA
Duration: Jan 20 1991Jan 22 1991

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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