Abstract
Optical coherence tomography (OCT) is a novel method for non-invasive sub-surface imaging of biological tissue micro-structure. OCT is based on low-coherence interferometry. OCT achieves high spatial resolution (approximately 15 μm in three dimensions) and high sensitivity (<-100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. We present in vitro cross-sectional OCT images obtained non-invasively in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. We also present a novel technique, termed color Doppler OCT (CDOCT) which is an extension of OCT for performing spatially localized optical Doppler velocimetry. We demonstrate micron-scale resolution tomographic imaging of bi-directional blood flow in sub-surface vessels in living tissue using CDOCT. Both OCT and CDOCT have several potential medical applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 883-886 |
| Number of pages | 4 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 2 |
| State | Published - 1997 |
| Externally published | Yes |
| Event | Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA Duration: Oct 30 1997 → Nov 2 1997 |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics