Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons

W. Zieglgänsberger; E. D. French; G. R. Seggins; F. E. Bloom

doi:10.1126/science.451610

Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons

W. Zieglgänsberger, E. D. French, G. R. Seggins, F. E. Bloom

Pharmacology

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the γ-aminobutyric acid antagonist bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing γ-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.

Original language	English (US)
Pages (from-to)	415-417
Number of pages	3
Journal	Science
Volume	205
Issue number	4404
DOIs	https://doi.org/10.1126/science.451610
State	Published - 1979

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abstract = "The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the γ-aminobutyric acid antagonist bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing γ-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.",

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AU - Seggins, G. R.

AU - Bloom, F. E.

PY - 1979

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Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons

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