Ontogeny of mammalian cardiac α1-adrenergic receptors

Shizuo Yamada; Henry I. Yamamura; William S. Roeske

doi:10.1016/0014-2999(80)90327-1

Ontogeny of mammalian cardiac α₁-adrenergic receptors

Shizuo Yamada
, Henry I. Yamamura
, William S. Roeske

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We find similar number of α₁-adrenergic receptors in fetal mouse hearts of 15–20 day gestational age as compared to adult mouse hearts, and a significantly greater number of α₁-adrenoceptors in the early neonate (7–21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low inthe fetus and increased continuously after birth to reach adult levels at about 21 days of age. Te cardiac α₁-adrenergic receptors prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decrease with innervation.

Original language	English (US)
Pages (from-to)	217-221
Number of pages	5
Journal	European Journal of Pharmacology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(80)90327-1
State	Published - 1980

Keywords

Cardiac α-adrenergic receptor
Development
Norepinephrine levels
[H]WB4101 binding

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(80)90327-1

Cite this

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title = "Ontogeny of mammalian cardiac α1-adrenergic receptors",

abstract = "We find similar number of α1-adrenergic receptors in fetal mouse hearts of 15–20 day gestational age as compared to adult mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7–21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low inthe fetus and increased continuously after birth to reach adult levels at about 21 days of age. Te cardiac α1-adrenergic receptors prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decrease with innervation.",

keywords = "Cardiac α-adrenergic receptor, Development, Norepinephrine levels, [H]WB4101 binding",

author = "Shizuo Yamada and Yamamura, \{Henry I.\} and Roeske, \{William S.\}",

note = "Funding Information: The authors would like to express their appreciation to Mr. Scott Ruth for his excellent technical assistance and to Mrs. Isabelle Preiss for her secretarial help. This work was supported in part by United States Public Health Service grants MH-27257 and MH-30626 and Program Project grant HL-20984. Shizuo Yamada is a recipient of a post-doctoral fellowship of the American Heart Association, Arizona Affiliate. Henry I. Yamamura is a recipient of a United States Public Health Service Research Scientist Development Award, Type II from the National Institute of Mental Health (MH-00095). William R. Roeske is a recipient of a USPHS RSDA from the NHLBI (HL-00776).",

year = "1980",

doi = "10.1016/0014-2999(80)90327-1",

language = "English (US)",

volume = "68",

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T1 - Ontogeny of mammalian cardiac α1-adrenergic receptors

AU - Yamada, Shizuo

AU - Yamamura, Henry I.

AU - Roeske, William S.

N1 - Funding Information: The authors would like to express their appreciation to Mr. Scott Ruth for his excellent technical assistance and to Mrs. Isabelle Preiss for her secretarial help. This work was supported in part by United States Public Health Service grants MH-27257 and MH-30626 and Program Project grant HL-20984. Shizuo Yamada is a recipient of a post-doctoral fellowship of the American Heart Association, Arizona Affiliate. Henry I. Yamamura is a recipient of a United States Public Health Service Research Scientist Development Award, Type II from the National Institute of Mental Health (MH-00095). William R. Roeske is a recipient of a USPHS RSDA from the NHLBI (HL-00776).

PY - 1980

Y1 - 1980

N2 - We find similar number of α1-adrenergic receptors in fetal mouse hearts of 15–20 day gestational age as compared to adult mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7–21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low inthe fetus and increased continuously after birth to reach adult levels at about 21 days of age. Te cardiac α1-adrenergic receptors prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decrease with innervation.

AB - We find similar number of α1-adrenergic receptors in fetal mouse hearts of 15–20 day gestational age as compared to adult mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7–21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low inthe fetus and increased continuously after birth to reach adult levels at about 21 days of age. Te cardiac α1-adrenergic receptors prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decrease with innervation.

KW - Cardiac α-adrenergic receptor

KW - Development

KW - Norepinephrine levels

KW - [H]WB4101 binding

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