The actions of estrogen are thought to be exerted via the estrogen receptor (ER), of which there are two isoforms, a and β. ERα and ERβ are intracellular receptors that belong to a large nuclear receptor superfamily of proteins. Estrogen receptors function directly as ligand-dependent transcription factors that regulate the synthesis of specific RNAs and proteins. The estrogen receptors are similar to most other steroid hormone receptors in that they exhibit a variable N-terminal region, a short and well-conserved cysteinerich central DNA binding domain, and a relatively well-conserved ligand binding carboxyl-terminal half.1 The carboxyl terminal domain is both structurally and functionally complex.
|Original language||English (US)|
|Title of host publication||Neuroplasticity, Development, and Steroid Hormone Action|
|Number of pages||21|
|ISBN (Print)||084930962X, 9780849309625|
|State||Published - Jan 1 2001|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)