Ontogeny and molecular characterization of estrogen receptors in the hippocampus

Robert J Handa, Richard H. Price, Cheryl A. Butler, Derek T. Solum

Research output: Chapter in Book/Report/Conference proceedingChapter


The actions of estrogen are thought to be exerted via the estrogen receptor (ER), of which there are two isoforms, a and β. ERα and ERβ are intracellular receptors that belong to a large nuclear receptor superfamily of proteins. Estrogen receptors function directly as ligand-dependent transcription factors that regulate the synthesis of specific RNAs and proteins. The estrogen receptors are similar to most other steroid hormone receptors in that they exhibit a variable N-terminal region, a short and well-conserved cysteinerich central DNA binding domain, and a relatively well-conserved ligand binding carboxyl-terminal half.1 The carboxyl terminal domain is both structurally and functionally complex.

Original languageEnglish (US)
Title of host publicationNeuroplasticity, Development, and Steroid Hormone Action
PublisherCRC Press
Number of pages21
ISBN (Electronic)9781420041194
ISBN (Print)084930962X, 9780849309625
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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