TY - JOUR
T1 - One-Step Synthesis of Thieno[2,3- d]pyrimidin-4(3 H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S 8 , and Formamide
AU - Shi, Taoda
AU - Kaneko, Lynn
AU - Sandino, Michael
AU - Busse, Ryan
AU - Zhang, Mae
AU - Mason, Damian
AU - Machulis, Jason
AU - Ambrose, Andrew J.
AU - Zhang, Donna D.
AU - Chapman, Eli
N1 - Funding Information:
*E-mail: [email protected]. ORCID Andrew J. Ambrose: 0000-0002-2932-4514 Eli Chapman: 0000-0002-6310-1664 Funding This work was supported by the National Institute Environmental Health Sciences (ES032758). Notes The authors declare no competing financial interest.
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2019/1/7
Y1 - 2019/1/7
N2 - Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S 8 , and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification.
AB - Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S 8 , and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification.
KW - Catalytic multicomponent reaction
KW - Thieno[2,3- d]pyrimidin-4(3 H)-ones
KW - green chemistry
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U2 - 10.1021/acssuschemeng.8b05276
DO - 10.1021/acssuschemeng.8b05276
M3 - Article
AN - SCOPUS:85059649826
SN - 2168-0485
VL - 7
SP - 1524
EP - 1528
JO - ACS Sustainable Chemistry and Engineering
JF - ACS Sustainable Chemistry and Engineering
IS - 1
ER -