Abstract
A concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates.
Original language | English (US) |
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Pages (from-to) | 627-635 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 69 |
Issue number | 2 |
DOIs | |
State | Published - Jan 14 2013 |
Externally published | Yes |
Keywords
- 3-substituted 4-aryl-2,4-diketoesters
- 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates
- Knorr reaction
- Lithium tert-butoxide
- Sterically hindered Claisen condensation
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry