Abstract
An unprecedented organocatalytic highly enantioselective cascade Michael-aldol reaction has been developed in high yields under mild reaction conditions. The "one-pot" process affords an efficient approach to the synthetically and biologically important chiral 4H-chromenes bearing a quaternary stereogenic center. The study significantly expands the scope of less explored organocatalytic iminium-allenamine chemistry.
Original language | English (US) |
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Pages (from-to) | 4948-4951 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 21 |
DOIs | |
State | Published - Nov 5 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry