"One-Pot" Access to 4 H-chromenes with formation of a chiral quaternary stereogenic center by a highly enantioselective iminium-allenamine involved oxa-Michael-aldol cascade

Chunliang Liu, Xinshuai Zhang, Rui Wang, Wei Wang

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

An unprecedented organocatalytic highly enantioselective cascade Michael-aldol reaction has been developed in high yields under mild reaction conditions. The "one-pot" process affords an efficient approach to the synthetically and biologically important chiral 4H-chromenes bearing a quaternary stereogenic center. The study significantly expands the scope of less explored organocatalytic iminium-allenamine chemistry.

Original languageEnglish (US)
Pages (from-to)4948-4951
Number of pages4
JournalOrganic Letters
Volume12
Issue number21
DOIs
StatePublished - Nov 5 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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