An unprecedented organocatalytic highly enantioselective cascade Michael-aldol reaction has been developed in high yields under mild reaction conditions. The "one-pot" process affords an efficient approach to the synthetically and biologically important chiral 4H-chromenes bearing a quaternary stereogenic center. The study significantly expands the scope of less explored organocatalytic iminium-allenamine chemistry.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry