Oncogenic transformation of human-derived gastric organoids

Nina Bertaux-Skeirik, Jomaris Centeno, Jian Gao, Joel Gabre, Yana Zavros

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


The culture of organoids has represented a significant advancement in the gastrointestinal research field. Previous research studies have described the oncogenic transformation of human intestinal and mouse gastric organoids. Here we detail the protocol for the oncogenic transformation and orthotopic transplantation of human-derived gastric organoids.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
StatePublished - 2019
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • CRISPR/Cas-9
  • Human fundic gastric organoids
  • Nucleofection
  • Organoid orthotopic transplantation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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