On the estimation of hypoxic ventilatory response

Richard M. Engeman, Duane L. Sherrill, George D. Swanson

Research output: Contribution to journalArticlepeer-review


The shape parameter, A, has been used to assess hypoxic sensitivity (ventilatory response, V ̇E, to lowered alveolar oxygen tension, PAO2) in the model of the form V ̇E = V ̇EO + A (PAO2 - C) where C is held constant at 32. In this paper we examine the consequence of holding C constant versus estimating both A and C from the data. Using computer-simulated data from 59 subjects whose A and C values had been previously determined, we indicate that when the actual C value is substantially different from 32, the model with C = 32 does not fit the data. In this case, the estimated A value with C = 32 is highly dependent upon the lowest value of PAO2 obtained in the experimental protocol and can be markedly different from the actual A value. In contrast, when C is also estimated from the subject's data the model fits the data and the estimate of A is unbiased but the precision may be diminished when the actual value of C is low. To improve this precision, we propose a Bayesian estimation scheme that adds a "soft" constraint on C.

Original languageEnglish (US)
Pages (from-to)553-562
Number of pages10
JournalComputers and Biomedical Research
Issue number6
StatePublished - Dec 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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