Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use

Christopher Cunniff; Kenneth Lyons Jones; Julia Phillipson; Kurt Benirschke; Sandra Short; Joseph Wujek

doi:10.1016/0002-9378(90)90846-Y

Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use

Christopher Cunniff, Kenneth Lyons Jones, Julia Phillipson, Kurt Benirschke, Sandra Short, Joseph Wujek

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.

Original language	English (US)
Pages (from-to)	187-189
Number of pages	3
Journal	American journal of obstetrics and gynecology
Volume	162
Issue number	1
DOIs	https://doi.org/10.1016/0002-9378(90)90846-Y
State	Published - Jan 1990
Externally published	Yes

Keywords

Enalapril
angiotensin converting enzyme inhibitors
captopril
renal dysgenesis

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(90)90846-Y

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title = "Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use",

abstract = "We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.",

keywords = "Enalapril, angiotensin converting enzyme inhibitors, captopril, renal dysgenesis",

author = "Christopher Cunniff and Jones, {Kenneth Lyons} and Julia Phillipson and Kurt Benirschke and Sandra Short and Joseph Wujek",

note = "Funding Information: From the DivisIOns of Dysmorphology and Neonatology, Department of Pedwtncs, and the Departments of Pathology and Reproductive MediCine, Unwerszty of California, San Diego. ThIS work was supported part by NatIOnal Institutes of Health grant AM-07318. ReCClvedfor publicatIOn April 7.1989; revlSedJune 5,1989; ac-cepted June 22, 1989. Repnnt requests: Christopher Cunniff, MD, Department of PedIat TICS, Slot 512, UmveTSlty of Arkansas for Medical SCIences, 4301 W. Markham St., Little Rock, AR 72205. 611114830",

year = "1990",

month = jan,

doi = "10.1016/0002-9378(90)90846-Y",

language = "English (US)",

volume = "162",

pages = "187--189",

journal = "American journal of obstetrics and gynecology",

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number = "1",

}

TY - JOUR

T1 - Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use

AU - Cunniff, Christopher

AU - Jones, Kenneth Lyons

AU - Phillipson, Julia

AU - Benirschke, Kurt

AU - Short, Sandra

AU - Wujek, Joseph

N1 - Funding Information: From the DivisIOns of Dysmorphology and Neonatology, Department of Pedwtncs, and the Departments of Pathology and Reproductive MediCine, Unwerszty of California, San Diego. ThIS work was supported part by NatIOnal Institutes of Health grant AM-07318. ReCClvedfor publicatIOn April 7.1989; revlSedJune 5,1989; ac-cepted June 22, 1989. Repnnt requests: Christopher Cunniff, MD, Department of PedIat TICS, Slot 512, UmveTSlty of Arkansas for Medical SCIences, 4301 W. Markham St., Little Rock, AR 72205. 611114830

PY - 1990/1

Y1 - 1990/1

N2 - We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.

AB - We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.

KW - Enalapril

KW - angiotensin converting enzyme inhibitors

KW - captopril

KW - renal dysgenesis

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JF - American journal of obstetrics and gynecology

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ER -

Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use

Abstract

Keywords

ASJC Scopus subject areas

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