Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Nicholas M. Papadopoulos; H. Clifford Lane; Rene Costello; Haralampos M. Moutsopoulos; Henry Masur; Edward P. Gelmann; Anthony S. Fauci

doi:10.1016/0090-1229(85)90076-5

Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Nicholas M. Papadopoulos, H. Clifford Lane, Rene Costello, Haralampos M. Moutsopoulos, Henry Masur, Edward P. Gelmann, Anthony S. Fauci

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

Original language	English (US)
Pages (from-to)	43-46
Number of pages	4
Journal	Clinical Immunology and Immunopathology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(85)90076-5
State	Published - Apr 1985
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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title = "Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome",

abstract = "Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.",

author = "Papadopoulos, {Nicholas M.} and Lane, {H. Clifford} and Rene Costello and Moutsopoulos, {Haralampos M.} and Henry Masur and Gelmann, {Edward P.} and Fauci, {Anthony S.}",

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AU - Papadopoulos, Nicholas M.

AU - Lane, H. Clifford

AU - Costello, Rene

AU - Moutsopoulos, Haralampos M.

AU - Masur, Henry

AU - Gelmann, Edward P.

AU - Fauci, Anthony S.

PY - 1985/4

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N2 - Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

AB - Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

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Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Abstract

ASJC Scopus subject areas

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