Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Nicholas M. Papadopoulos, H. Clifford Lane, Rene Costello, Haralampos M. Moutsopoulos, Henry Masur, Edward P. Gelmann, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalClinical Immunology and Immunopathology
Volume35
Issue number1
DOIs
StatePublished - Apr 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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