Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Nicholas M. Papadopoulos; H. Clifford Lane; Rene Costello; Haralampos M. Moutsopoulos; Henry Masur; Edward P. Gelmann; Anthony S. Fauci

doi:10.1016/0090-1229(85)90076-5

Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Nicholas M. Papadopoulos, H. Clifford Lane, Rene Costello, Haralampos M. Moutsopoulos, Henry Masur, Edward P. Gelmann, Anthony S. Fauci

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.

Original language	English (US)
Pages (from-to)	43-46
Number of pages	4
Journal	Clinical Immunology and Immunopathology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(85)90076-5
State	Published - Apr 1985
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome. / Papadopoulos, Nicholas M.; Lane, H. Clifford; Costello, Rene; Moutsopoulos, Haralampos M.; Masur, Henry; Gelmann, Edward P.; Fauci, Anthony S.

In: Clinical Immunology and Immunopathology, Vol. 35, No. 1, 04.1985, p. 43-46.

Research output: Contribution to journal › Article › peer-review

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abstract = "Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24 27 patients with Kaposi's sarcoma and in 2 15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.",

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AU - Gelmann, Edward P.

AU - Fauci, Anthony S.

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Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome

Abstract

ASJC Scopus subject areas

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