Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

Arunima Kapoor; Shubir Dutt; John Paul M. Alitin; Isabel J. Sible; Anisa Marshall; Fatemah Shenasa; Allison C. Engstrom; Aimée Gaubert; Xingfeng Shao; David Robert Bradford; Kathleen Rodgers; Mara Mather; Danny J.J. Wang; Daniel A. Nation

doi:10.1016/j.neurobiolaging.2024.03.006

Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

Arunima Kapoor, Shubir Dutt, John Paul M. Alitin, Isabel J. Sible, Anisa Marshall, Fatemah Shenasa, Allison C. Engstrom, Aimée Gaubert, Xingfeng Shao, David Robert Bradford, Kathleen Rodgers, Mara Mather, Danny J.J. Wang, Daniel A. Nation

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = −.02, 95% CI (-.04, −.008), p =.003] and in APOE4 carriers [B = −.03, 95% CI (-.06, −.009), p =.009]. Findings suggest deficits in cerebral vasodilatory capacity are associated with WMH burden in older adults and future studies are warranted to further delineate the effect of APOE4 on precipitating WMH.

Original language	English (US)
Pages (from-to)	5-10
Number of pages	6
Journal	Neurobiology of Aging
Volume	139
DOIs	https://doi.org/10.1016/j.neurobiolaging.2024.03.006
State	Published - Jul 2024
Externally published	Yes

Keywords

Cerebrovascular reactivity
Small Vessel disease
White matter hyperintensities

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2024.03.006

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Kapoor, A., Dutt, S., Alitin, J. P. M., Sible, I. J., Marshall, A., Shenasa, F., Engstrom, A. C., Gaubert, A., Shao, X., Bradford, D. R., Rodgers, K., Mather, M., Wang, D. J. J., & Nation, D. A. (2024). Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden. Neurobiology of Aging, 139, 5-10. https://doi.org/10.1016/j.neurobiolaging.2024.03.006

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title = "Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden",

abstract = "Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = −.02, 95% CI (-.04, −.008), p =.003] and in APOE4 carriers [B = −.03, 95% CI (-.06, −.009), p =.009]. Findings suggest deficits in cerebral vasodilatory capacity are associated with WMH burden in older adults and future studies are warranted to further delineate the effect of APOE4 on precipitating WMH.",

keywords = "Cerebrovascular reactivity, Small Vessel disease, White matter hyperintensities",

author = "Arunima Kapoor and Shubir Dutt and Alitin, {John Paul M.} and Sible, {Isabel J.} and Anisa Marshall and Fatemah Shenasa and Engstrom, {Allison C.} and Aim{\'e}e Gaubert and Xingfeng Shao and Bradford, {David Robert} and Kathleen Rodgers and Mara Mather and Wang, {Danny J.J.} and Nation, {Daniel A.}",

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year = "2024",

month = jul,

doi = "10.1016/j.neurobiolaging.2024.03.006",

language = "English (US)",

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T1 - Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

AU - Kapoor, Arunima

AU - Dutt, Shubir

AU - Alitin, John Paul M.

AU - Sible, Isabel J.

AU - Marshall, Anisa

AU - Shenasa, Fatemah

AU - Engstrom, Allison C.

AU - Gaubert, Aimée

AU - Shao, Xingfeng

AU - Bradford, David Robert

AU - Rodgers, Kathleen

AU - Mather, Mara

AU - Wang, Danny J.J.

AU - Nation, Daniel A.

PY - 2024/7

Y1 - 2024/7

N2 - Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = −.02, 95% CI (-.04, −.008), p =.003] and in APOE4 carriers [B = −.03, 95% CI (-.06, −.009), p =.009]. Findings suggest deficits in cerebral vasodilatory capacity are associated with WMH burden in older adults and future studies are warranted to further delineate the effect of APOE4 on precipitating WMH.

AB - Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = −.02, 95% CI (-.04, −.008), p =.003] and in APOE4 carriers [B = −.03, 95% CI (-.06, −.009), p =.009]. Findings suggest deficits in cerebral vasodilatory capacity are associated with WMH burden in older adults and future studies are warranted to further delineate the effect of APOE4 on precipitating WMH.

KW - Cerebrovascular reactivity

KW - Small Vessel disease

KW - White matter hyperintensities

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ER -

Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

Abstract

Keywords

ASJC Scopus subject areas

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