Abstract
A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.
Original language | English (US) |
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Pages (from-to) | 512-513 |
Number of pages | 2 |
Journal | Nature Genetics |
Volume | 41 |
Issue number | 5 |
DOIs | |
State | Published - May 2009 |
ASJC Scopus subject areas
- Genetics