TY - JOUR
T1 - Occupational Years of Service and Leukocyte Epigenetic Aging
T2 - Relationships in United States Firefighters
AU - Nwanaji-Enwerem, Jamaji C.
AU - Cardenas, Andres
AU - Goodrich, Jaclyn M.
AU - Furlong, Melissa A.
AU - Jung, Alesia M.
AU - Collender, Philip A.
AU - Caban-Martinez, Alberto J.
AU - Grant, Casey
AU - Beitel, Shawn C.
AU - Littau, Sally
AU - Urwin, Derek J.
AU - Gabriel, Jamie J.
AU - Hughes, Jeff
AU - Gulotta, John
AU - Wallentine, Darin
AU - Burgess, Jefferey L.
N1 - Publisher Copyright:
© 2023 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Objective: The aim of the study is to examine associations between years of firefighting service and eight chronological age-adjusted measures of blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length. Methods The study used a repeated measures analysis of data from 379 incumbent firefighters from eight career departments and 100 recruit firefighters from two of the departments, across the United States. Results Incumbent firefighters had on average greater epigenetic age acceleration compared with recruit firefighters, potentially due to the cumulative effect of occupational exposures. However, among incumbent firefighters, additional years of service were associated with epigenetic age deceleration, particularly for GrimAge, a strong predictor of mortality. Conclusions Long-term studies with more specific occupational exposure classification are needed to better understand the relationship between years of service and aging biomarkers.
AB - Objective: The aim of the study is to examine associations between years of firefighting service and eight chronological age-adjusted measures of blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length. Methods The study used a repeated measures analysis of data from 379 incumbent firefighters from eight career departments and 100 recruit firefighters from two of the departments, across the United States. Results Incumbent firefighters had on average greater epigenetic age acceleration compared with recruit firefighters, potentially due to the cumulative effect of occupational exposures. However, among incumbent firefighters, additional years of service were associated with epigenetic age deceleration, particularly for GrimAge, a strong predictor of mortality. Conclusions Long-term studies with more specific occupational exposure classification are needed to better understand the relationship between years of service and aging biomarkers.
KW - DNA methylation
KW - EMS
KW - EMT
KW - epigenetic age
KW - healthy worker effect
UR - http://www.scopus.com/inward/record.url?scp=85159339521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159339521&partnerID=8YFLogxK
U2 - 10.1097/JOM.0000000000002817
DO - 10.1097/JOM.0000000000002817
M3 - Article
C2 - 36787539
AN - SCOPUS:85159339521
SN - 1076-2752
VL - 65
SP - E312-E318
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 5
ER -