Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study

Stuart F. Quan, Ron Wright, Carol M. Baldwin, Kristine L. Kaemingk, James L. Goodwin, Tracy F. Kuo, Alfred Kaszniak, Lori L. Boland, Elise Caccappolo, Richard R. Bootzin

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Background and purpose: Obstructive sleep apnea-hypopnea (OSAH) is associated with sleep fragmentation and nocturnal hypoxemia. In clinical samples, patients with OSAH frequently are found to have deficits in neuropsychological function. However, the nature and severity of these abnormalities in non-clinical populations is less well defined. Patients and methods: One hundred and forty-one participants from the Tucson, AZ and New York, NY field centers of the Sleep Heart Health Study completed a battery of neuropsychological tests for 9-40 months (mean=24 months, SD=7 months) after an unattended home polysomnogram. Sixty-seven participants had OSAH (AHI>10) and 74 did not have OSAH (control (CTL), apnea-hypopnea index (AHI)<5). In addition to the individual tests, composite variables representing attention, executive function, MotorSpeed and processing speed were constructed from the neuropsychological test battery. Results: There were no significant differences in any individual neuropsychological test or composite variable between the OSAH and CTL groups. However, when time spent with O2 saturations less than 85% was dichotomized into those participants in the top quartile of the distribution and those in the lower three quartiles, motor speed was significantly impaired in those who were more hypoxemic. In addition, poorer motor speed (model adjusted R2=0.242, P<0.001) and processing speed performance (model adjusted R2=0.122, P<0.001) were associated with more severe oxygen desaturation even after controlling for degree of daytime sleepiness, age, gender and educational level. Conclusions: Mild to moderate OSAH has little impact on the selected measures of attention, executive function, motor speed and processing speed. However, hypoxemia adversely affects both motor and processing speed. These results suggest that in middle-aged to elderly adults the neuropsychological effects of clinically unrecognized mild to moderate OSAH are neither global nor large.

Original languageEnglish (US)
Pages (from-to)498-507
Number of pages10
JournalSleep Medicine
Issue number6
StatePublished - Sep 2006


  • Hypoxemia
  • Neurocognitive function
  • Neuropsychologic function
  • Obstructive sleep apnea
  • Sleep disordered breathing
  • epidomiology

ASJC Scopus subject areas

  • General Medicine


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