TY - JOUR
T1 - Oblique incidence reflectometry
T2 - Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system
AU - Wall, R. Andrew
AU - Barton, Jennifer K.
N1 - Funding Information:
Research reported in this paper was supported by the National Cancer Institute of the National Institutes of Health under Award No. R01 CA109385. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2014/6
Y1 - 2014/6
N2 - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.
AB - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.
KW - absorption coefficient
KW - colon.
KW - endoscope
KW - gastrointestinal
KW - gradient-index
KW - oblique incidence reflectometry
KW - reduced scattering coefficient
KW - tissue optical properties
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U2 - 10.1117/1.JBO.19.6.067002
DO - 10.1117/1.JBO.19.6.067002
M3 - Article
C2 - 24892970
AN - SCOPUS:84902097100
SN - 1083-3668
VL - 19
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 6
M1 - 067002
ER -