Obesity and leptin in breast cancer angiogenesis

Courtney B. Lagarde; Kapil Thapa; Nicole M. Cullen; Mackenzie L. Hawes; Khudeja Salim; Megan C. Benz; Sophie R. Dietrich; Brandon E. Burow; Bruce A. Bunnell; Elizabeth C. Martin; Bridgette M. Collins-Burow; Ronald M. Lynch; Van T. Hoang; Matthew E. Burow; Jennifer S. Fang

doi:10.3389/fendo.2024.1465727

Obesity and leptin in breast cancer angiogenesis

Courtney B. Lagarde, Kapil Thapa, Nicole M. Cullen, Mackenzie L. Hawes, Khudeja Salim, Megan C. Benz, Sophie R. Dietrich, Brandon E. Burow, Bruce A. Bunnell, Elizabeth C. Martin, Bridgette M. Collins-Burow, Ronald M. Lynch, Van T. Hoang, Matthew E. Burow, Jennifer S. Fang

Research output: Contribution to journal › Review article › peer-review

Abstract

At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm³ in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.

Original language	English (US)
Article number	1465727
Journal	Frontiers in Endocrinology
Volume	15
DOIs	https://doi.org/10.3389/fendo.2024.1465727
State	Published - 2024
Externally published	Yes

Keywords

angiogenesis
breast cancer
hyperleptinemia
leptin
obesity
tumor microenvironment

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.3389/fendo.2024.1465727

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title = "Obesity and leptin in breast cancer angiogenesis",

abstract = "At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.",

keywords = "angiogenesis, breast cancer, hyperleptinemia, leptin, obesity, tumor microenvironment",

author = "Lagarde, {Courtney B.} and Kapil Thapa and Cullen, {Nicole M.} and Hawes, {Mackenzie L.} and Khudeja Salim and Benz, {Megan C.} and Dietrich, {Sophie R.} and Burow, {Brandon E.} and Bunnell, {Bruce A.} and Martin, {Elizabeth C.} and Collins-Burow, {Bridgette M.} and Lynch, {Ronald M.} and Hoang, {Van T.} and Burow, {Matthew E.} and Fang, {Jennifer S.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Lagarde, Thapa, Cullen, Hawes, Salim, Benz, Dietrich, Burow, Bunnell, Martin, Collins-Burow, Lynch, Hoang, Burow and Fang.",

year = "2024",

doi = "10.3389/fendo.2024.1465727",

language = "English (US)",

volume = "15",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Obesity and leptin in breast cancer angiogenesis

AU - Lagarde, Courtney B.

AU - Thapa, Kapil

AU - Cullen, Nicole M.

AU - Hawes, Mackenzie L.

AU - Salim, Khudeja

AU - Benz, Megan C.

AU - Dietrich, Sophie R.

AU - Burow, Brandon E.

AU - Bunnell, Bruce A.

AU - Martin, Elizabeth C.

AU - Collins-Burow, Bridgette M.

AU - Lynch, Ronald M.

AU - Hoang, Van T.

AU - Burow, Matthew E.

AU - Fang, Jennifer S.

PY - 2024

Y1 - 2024

N2 - At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.

AB - At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.

KW - angiogenesis

KW - breast cancer

KW - hyperleptinemia

KW - leptin

KW - obesity

KW - tumor microenvironment

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U2 - 10.3389/fendo.2024.1465727

DO - 10.3389/fendo.2024.1465727

M3 - Review article

AN - SCOPUS:85207032514

SN - 1664-2392

VL - 15

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 1465727

ER -

Obesity and leptin in breast cancer angiogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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