O-Benzyl-N- t-butyloxycarbonyl- L-serine

Victor J. Heuby; Kenneth W. Ehler

doi:10.1021/jo00830a100

O-Benzyl-N- t-butyloxycarbonyl- L-serine

Victor J. Heuby, Kenneth W. Ehler

Chemistry and Biochemistry

Research output: Contribution to journal › Comment/debate › peer-review

21 Scopus citations

Abstract

In solid-phase peptide synthesis, it is desirable to incorporate both serine and threonine as their O-ben-zyl-N-acyloxycarbonyl derivatives.8 Recently, a simple method for preparing O-benzyl-N-if-butyloxycarbonyl-L-threonine was reported.4 On the other hand, methods for preparing O-benzyl-N-i-butyloxycarbonyl-L-serine are very laborious.6-6 The present study reports a simple two-step synthesis of O-benzyl-N-i-butyloxycarbonyl-L-serine from L-serine.

Original language	English (US)
Pages (from-to)	1690
Number of pages	1
Journal	Journal of Organic Chemistry
Volume	35
Issue number	5
DOIs	https://doi.org/10.1021/jo00830a100
State	Published - May 1 1970

ASJC Scopus subject areas

Organic Chemistry

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@article{0dc9d6b3041d44be959efe208b13375d,

title = "O-Benzyl-N- t-butyloxycarbonyl- L-serine",

abstract = "In solid-phase peptide synthesis, it is desirable to incorporate both serine and threonine as their O-ben-zyl-N-acyloxycarbonyl derivatives.8 Recently, a simple method for preparing O-benzyl-N-if-butyloxycarbonyl-L-threonine was reported.4 On the other hand, methods for preparing O-benzyl-N-i-butyloxycarbonyl-L-serine are very laborious.6-6 The present study reports a simple two-step synthesis of O-benzyl-N-i-butyloxycarbonyl-L-serine from L-serine.",

author = "Heuby, {Victor J.} and Ehler, {Kenneth W.}",

year = "1970",

month = may,

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doi = "10.1021/jo00830a100",

language = "English (US)",

volume = "35",

pages = "1690",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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TY - JOUR

T1 - O-Benzyl-N- t-butyloxycarbonyl- L-serine

AU - Heuby, Victor J.

AU - Ehler, Kenneth W.

PY - 1970/5/1

Y1 - 1970/5/1

N2 - In solid-phase peptide synthesis, it is desirable to incorporate both serine and threonine as their O-ben-zyl-N-acyloxycarbonyl derivatives.8 Recently, a simple method for preparing O-benzyl-N-if-butyloxycarbonyl-L-threonine was reported.4 On the other hand, methods for preparing O-benzyl-N-i-butyloxycarbonyl-L-serine are very laborious.6-6 The present study reports a simple two-step synthesis of O-benzyl-N-i-butyloxycarbonyl-L-serine from L-serine.

AB - In solid-phase peptide synthesis, it is desirable to incorporate both serine and threonine as their O-ben-zyl-N-acyloxycarbonyl derivatives.8 Recently, a simple method for preparing O-benzyl-N-if-butyloxycarbonyl-L-threonine was reported.4 On the other hand, methods for preparing O-benzyl-N-i-butyloxycarbonyl-L-serine are very laborious.6-6 The present study reports a simple two-step synthesis of O-benzyl-N-i-butyloxycarbonyl-L-serine from L-serine.

UR - http://www.scopus.com/inward/record.url?scp=0343967608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343967608&partnerID=8YFLogxK

U2 - 10.1021/jo00830a100

DO - 10.1021/jo00830a100

M3 - Comment/debate

AN - SCOPUS:0343967608

SN - 0022-3263

VL - 35

SP - 1690

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 5

ER -

O-Benzyl-N- t-butyloxycarbonyl- L-serine

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