Separation control mechanisms in low-pressure turbine (LPT) applications are investigated numerically. Two-dimensional simulations of boundary layer separation on the suction side of a turbine blade in a linear cascade are presented and compared to experimental data. Active flow control by means of pulsed blowing is employed and its impact on the separation behavior is discussed. Fundamental separation control mechanisms associated with steady and pulsed vortex generator jets (VGJs) are investigated by direct numerical simulations of a separating boundary layer under conditions comparable to those in low Reynolds number LPT applications. The vortex generator jets are employed in two configurations, vertical as well as angled with respect to the freestream direction. Our results confirm experimental findings that pulsed jet blowing is more effective than steady jet blowing. In addition, pulsed VGJs that are injected vertically are shown to achieve the greatest reduction in the extent of boundary layer separation.