@article{6ccdd683e1df47bba859133c240fbfc8,
title = "Nucleic acid–based testing for noninfluenza viral pathogens in adults with suspected community-acquired pneumonia: An official american thoracic society clinical practice guideline",
abstract = "Background: This document provides evidence-based clinical practice guidelines on the diagnostic utility of nucleic acid–based testing of respiratory samples for viral pathogens other than influenza in adults with suspected community-acquired pneumonia (CAP). Methods: A multidisciplinary panel developed a Population–Intervention–Comparison–Outcome question, conducted a pragmatic systematic review, and applied Grading of Recommendations, Assessment, Development, and Evaluation methodology for clinical recommendations. Results: The panel evaluated the literature to develop recommendations regarding whether routine diagnostics should include nucleic acid–based testing of respiratory samples for viral pathogens other than influenza in suspected CAP. The evidence addressing this topic was generally adjudicated to be of very low quality because of risk of bias and imprecision. Furthermore, there was little direct evidence supporting a role for routine nucleic acid–based testing of respiratory samples in improving critical outcomes such as overall survival or antibiotic use patterns. However, on the basis of direct and indirect evidence, recommendations were made for both outpatient and hospitalized patients with suspected CAP. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was not addressed in the literature at the time of the evidence review. Conclusions: The panel formulated and provided their rationale for recommendations on nucleic acid–based diagnostics for viral pathogens other than influenza for patients with suspected CAP.",
keywords = "Community-acquired pneumonia, Pneumonia, Viral diagnostics",
author = "{Dela Cruz}, {Charles S.} and Evans, {Scott E.} and Azar, {Marwan M.} and Bin Cao and Kristina Crothers and Dickson, {Robert P.} and Susanne Herold and Seema Jain and Jennerich, {Ann L.} and Ann Madhavan and Metersky, {Mark L.} and Myers, {Laura C.} and Eyal Oren and Restrepo, {Marcos I.} and Makeda Semret and Ajay Sheshadri and Wunderink, {Richard G.}",
note = "Funding Information: Supported by funding provided by the American Thoracic Society. Funding Information: Author Disclosures: S.E.E. had financial stake in, commercialized intellectual property with (PUL-042), and U.S. patent 8,883,174 with Pulmotect. B.C. served on an advisory committee for Roche; and received research support from BioMerieux, Cepheid, and Peking Union Medical College Foundation. A.L.J. received research support from The National Heart, Lung, and Blood Institute. M.L.M. served on an advisory committee for Arsanis, International Biophysics, Savara, Shionogi, and Zambon; served as a consultant for Arsanis, Dynamed, Insmed, International Biophysics, Savara, Shionogi, Zambon, and various law firms; served on a data safety and monitoring board for Lungpacer; served as a speaker for Prime Education; and received research support from Insmed, Multiclonal Therapeutics, and resTORbio. A.S. served as a consultant for PsiOxus Therapeutics. R.G.W. served on an advisory committee for Accelerate, bioMerieux, and Merck; served as a consultant for Accelerate Diagnostics, bioMerieux, GlaxoSmithKline, KBP Biosciences, La Jolla, Merck, Melinta, Microbiotix, Nabriva, Polyphor, ResTORBio, and Shionogi; served on a data and safety monitoring board for Vir Biotechnology and Pfizer; served as a speaker for bioMerieux and WebMD; and received research support from bioMerieux and Curetis. C.S.D.C., M.M.A., K.C., R.P.D., S.H., S.J., A.M., L.C.M., E.O., M.I.R., and M.S., reported no commercial or relevant noncommercial interests. Publisher Copyright: Copyright {\textcopyright} 2021 by the American Thoracic Society.",
year = "2021",
month = may,
day = "1",
doi = "10.1164/rccm.202102-0498ST",
language = "English (US)",
volume = "203",
pages = "1070--1087",
journal = "American journal of respiratory and critical care medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "9",
}