NTHL1 in genomic integrity, aging and cancer

Lipsa Das, Victoria G. Quintana, Joann B. Sweasy

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Efficient DNA repair is essential to maintain genomic integrity. An average of 30,000 base lesions per cell are removed daily by the DNA glycosylases of the base excision repair machinery. With the advent of whole genome sequencing, many germline mutations in these DNA glycosylases have been identified and associated with various diseases, including cancer. In this graphical review, we discuss the function of the NTHL1 DNA glycosylase and how genomic mutations and altered function of this protein contributes to cancer and aging. We highlight its role in a rare tumor syndrome, NTHL1-associated polyposis (NAP), and summarize various other polymorphisms in NTHL1 that can induce early hallmarks of cancer, including genomic instability and cellular transformation.

Original languageEnglish (US)
Article number102920
JournalDNA Repair
Volume93
DOIs
StatePublished - Sep 2020

Keywords

  • Base excision repair
  • DNA glycosylase
  • DNA repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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