NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega; Eli Chapman; Donna D. Zhang

doi:10.1016/j.ccell.2018.03.022

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang

Research output: Contribution to journal › Review article › peer-review

1162 Scopus citations

Abstract

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

Original language	English (US)
Pages (from-to)	21-43
Number of pages	23
Journal	Cancer Cell
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2018.03.022
State	Published - Jul 9 2018

Keywords

KEAP1
NRF2
antioxidant response element (ARE)
cancer initiation and progression
carcinogenesis
chemoresistance
metabolic reprogramming
metastasis
oxidative stress

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccell.2018.03.022

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title = "NRF2 and the Hallmarks of Cancer",

abstract = "The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.",

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AU - Zhang, Donna D.

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AB - The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

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KW - cancer initiation and progression

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KW - chemoresistance

KW - metabolic reprogramming

KW - metastasis

KW - oxidative stress

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NRF2 and the Hallmarks of Cancer

Abstract

Keywords

ASJC Scopus subject areas

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